Excessive amounts of mu heavy chain block B-cell development
نویسندگان
چکیده
منابع مشابه
Excessive amounts of mu heavy chain block B-cell development.
Antigen-independent B-cell development occurs in several stages that depend on the expression of Ig heavy and light chain. We identified a line of mice that lacked mature B cells in the spleen. This mouse line carried approximately 11 copies of a transgene of the murine heavy chain constant region locus, and B-lineage cells expressed excessive amounts of the intracellular μ heavy chain. B-cell ...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2011
ISSN: 0953-8178,1460-2377
DOI: 10.1093/intimm/dxr049